RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Tgfbr2
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
Dual-luciferase reporter assay; qRT-PCR; etc.
Target
Tgfbr2
Pathway
NA
PubMed ID
Title
The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis
Year
2015
Function
MiR-153 expression was dysregulated in the lungs of mice with experimental pulmonary fibrosis and TGF-B1 decreased miR-153 expression in pulmonary fibroblasts. MiR-153 disturbs TGF-B1 signal transduction and its effects on fibroblast activation by post-transcriptional regulation of the expression of TGFBR2.